How Long Does Methadone Stay in Your System?

Methadone is commonly used as part of medication-assisted treatment (MAT) and a comprehensive addiction treatment program for people with opioid use disorder (OUD). Methadone blocks the euphoric effects of opioids while also lessening the severity of opioid withdrawal systems. Some people need to use this drug long-term to help reduce the risk of relapse. Finding out how long does methadone stays in your system is essential if you or a loved one take this medication. 

Understanding the Half-Life of Methadone

All medications have a half-life, which is the amount of time it takes the body to process and eliminate half of a dose. The half-life of methadone varies depending on the dosage and frequency of use. Generally, it can range from as little as eight hours to as long as 60 hours. 

It is important to mention that the effects of methadone usually last for a shorter period and can range from four hours up to 48 hours. However, even after the effects wear off, traces of methadone can remain within the body. Therefore, the body may take five or six half-lives to eliminate all traces of methadone.

Detecting Methadone: Drug Testing and Detection Windows

Drug tests can detect methadone long after its effects wear off. The detection window depends on the type of test being performed, as follows:

• Blood test: Methadone can be detected in blood tests up to 60 hours after the last dose was taken. 
• Urine test: Since the kidneys are responsible for metabolizing and eliminating methadone from the body, it can take them as long as two weeks before methadone is no longer detectable in urine. 
• Hair follicle test: As with other substances, methadone can be detected in hair samples up to three months after the last dose was taken. 

Saliva tests rarely detect methadone reliably, so most professionals avoid using them. However, researchers have found methadone in saliva up to 48 hours after the last dose.

The Impact of Dosage on How Long Methadone Lasts in Your System

How long methadone stays in your system is directly related to the dosage taken. Methadone is a long-acting opioid, which means it takes longer for the body to process and eliminate the drug from the system fully. Some key things to remember are:

• Higher dosages mean longer duration: Taking higher doses of methadone will increase the half-life time of the drug as well as the amount of time it can be detected on drug tests. 
• Methadone accumulation in the body: When methadone is taken long-term as part of MAT, consistent usage results in the body storing the drug in various tissues. This will directly impact the amount of time the drug remains in the body and is detectable on drug tests.
• Individual factors: The length of time methadone remains in the system depends on individual factors, including age, overall health, metabolism rate, and liver and kidney function. 

Factors That Affect Methadone Withdrawal and Detox

Long-term methadone use can lead to dependence on the drug. Once people stop using the drug, they may experience withdrawal symptoms as their body goes through detox. Some of the factors that influence methadone withdrawal and detox include:

• Dosage levels
• Duration of use
• Metabolism rate
• Presence of any co-occurring disorders
• Overall health
• Whether the person is following a tapering schedule
• Whether medically supervised detox is being used

Methadone and Treatment: What Patients Need to Know

Before beginning methadone as part of MAT and a comprehensive addiction treatment program for OUD, patients should be aware of the following:

• Methadone treatment is a long-term treatment plan. 
• Methadone is an opioid medication, so long-term use can lead to dependence.
• People can experience withdrawal symptoms when discontinuing the medication.
• Methadone therapy helps reduce the risk of relapse and makes withdrawal symptoms easier to manage.
• The duration of treatment will vary from one person to another based on the severity of their OUD.
• Patients should take methadone only under medical supervision.
• Patients should not attempt to self-medicate or adjust dosages or dosing schedules. 
• Methadone can have potential side effects, such as constipation, drowsiness, or sweating. 

How to Detox Methadone from Your System Safely

Detoxing from methadone can be challenging because people still experience withdrawal symptoms once they discontinue the medication. Some of the different options available to safely detox from methadone include:

• Medically supervised detox: Medical supervision ensures individuals have care and support to address and manage withdrawal symptoms. 
• Tapering: Gradually reducing the dosage of methadone over time can make it easier to quit entirely while minimizing the extent of withdrawal symptoms experienced. 
• Outpatient treatment programs: People who require extra support, counseling, and therapy to discontinue methadone can benefit from an appropriate outpatient treatment program.
• Support groups: Attending group support meetings can help people learn from others and how they safely quit using methadone. 
• Holistic therapies: Meditation, mindfulness, yoga, art therapy, and other forms of holistic therapies, combined with proper nutrition and exercise, can make it easier to detox from methadone safely. 

Begin Methadone Detox in Southern California Today

If you are looking for a safe and effective way to discontinue methadone, help is available at Phoenix Rising Recovery. We offer comprehensive and personalized methadone detox and treatment programs to fit your specific needs. Together, we can help you safely discontinue methadone and maintain your recovery progress. Contact us today for further information or to start the admissions process.

Published: 3/27/2025