RP 10 vs RP 10 325 Pill: What They Are, Differences, and Risks

If you’ve come across a pill labeled “RP 10” or “RP 10 325,” you’re not alone. These are commonly searched because they’re frequently prescribed, but they’re also commonly counterfeited.

Understanding what these pills actually are, how they differ, and why misidentification can be dangerous is more important than ever.

What Is an RP 10 Pill?

An RP 10 pill is a prescription medication that contains:

• 10 mg oxycodone hydrochloride
• Immediate-release opioid pain medication
• Typically prescribed for moderate to severe pain

It is a white, round tablet with the imprint “R P 10.”

Oxycodone is a Schedule II controlled substance due to its high potential for misuse and dependence.

What Is an RP 10 325 Pill?

An RP 10 325 pill is a combination medication that contains:

• 10 mg oxycodone
• 325 mg acetaminophen

This is similar to what many people know as Percocet.

It’s also used for pain relief, but the added acetaminophen changes both how it works and its risks.

RP 10 vs RP 10 325: Key Differences

Feature	RP 10	RP 10 325
Main ingredient	Oxycodone only	Oxycodone + acetaminophen
Strength	10 mg oxycodone	10 mg oxycodone + 325 mg acetaminophen
Common use	Moderate to severe pain	Pain with added anti-inflammatory effect
Liver risk	Lower (no acetaminophen)	Higher due to acetaminophen
Brand equivalent	Generic oxycodone	Similar to Percocet

The key takeaway is simple: RP 10 is pure oxycodone, while RP 10 325 is a combination drug.

Why These Pills Are Commonly Confused

Both pills:

• Are white and round
• Have very similar imprints
• Contain the same opioid dose

At a glance, they can look nearly identical. That’s why people often search for them interchangeably.

The Bigger Concern: Counterfeit Pills

Here’s where things get serious. Both RP 10 and RP 10 325 are among the pills most frequently copied in counterfeit drug markets. Fake versions may contain:

• Fentanyl
• Synthetic opioids
• Unknown or inconsistent substances

And they are often designed to look nearly identical to real pills.

Can You Tell If an RP 10 Pill Is Fake?

There are some possible red flags:

• Imprint looks uneven or smudged
• Texture is chalky or crumbly
• Color is slightly off
• Effects feel unusually strong or fast

But here’s the reality:

You cannot reliably confirm a pill is real just by looking at it. Even experienced professionals can’t always tell without testing.

Why RP 10 325 Has Additional Risk

Because RP 10 325 contains acetaminophen, it comes with an added layer of risk.

High doses of acetaminophen can cause:

• Liver damage
• Liver failure
• Increased danger when combined with alcohol

So misuse of this version carries both opioid risk and liver toxicity risk.

What Happens If You Take the Wrong Pill?

Taking a pill that isn’t what you think it is can lead to:

• Overdose
• Severe sedation
• Breathing suppression
• Organ damage
• Death in extreme cases

This is especially true when counterfeit pills are involved.

Safe Rule to Follow

If a pill:

• Didn’t come from a pharmacy
• Was given to you by someone else
• Was purchased online or off the street

You should assume it may not be what it says it is.

When Use Turns Into Risk

Oxycodone is effective for pain, but it also carries a high potential for:

• Dependence
• Tolerance
• Misuse
• Withdrawal symptoms

For many people, what starts as pain management can gradually shift into something harder to control.

Getting Help Without Judgment

At Phoenix Rising Recovery, we work with people at every stage of opioid use, whether it’s:

• Prescription misuse
• Dependence
• Transition to stronger substances
• Concerns about counterfeit exposure

Treatment is built around:

• Safe detox when needed
• Medication-assisted options
• Therapy and long-term recovery planning

The goal is not just stopping use, but helping you feel stable and clear again.

Final Thoughts

RP 10 and RP 10 325 pills may look similar, but they are not the same, and the risks today go beyond just misuse.

With counterfeit pills in circulation, the margin for error is gone. What looks like a standard prescription pill may be something entirely different.

If there’s any uncertainty around what you’re taking or how often you’re relying on it, it’s worth taking a step back and looking at safer options moving forward.

Frequently Asked Questions About RP 10 and RP 10 325 tablets

Sources

1. Drugs.com. (n.d.). R P 10 pill: White, round, 7mm. Retrieved from https://www.drugs.com/imprints/r-p-10-16896.html
2. Drug Enforcement Administration. (n.d.). One pill can kill. U.S. Department of Justice. Retrieved from https://www.dea.gov/onepill
3. Drug Enforcement Administration. (2021, October 1). DEA issues public safety alert on sharp increase in fake prescription pills containing fentanyl and meth. U.S. Department of Justice. Retrieved from https://www.dea.gov/press-releases/2021/10/01/dea-issues-public-safety-alert-sharp-increase-fake-prescription-pills
4. Centers for Disease Control and Prevention. (2025, June 9). Understanding the opioid overdose epidemic. Retrieved from https://www.cdc.gov/overdose-prevention/about/understanding-the-opioid-overdose-epidemic.html
5. MedlinePlus. (2026, January 15). Oxycodone: Drug information. U.S. National Library of Medicine. Retrieved April 1, 2026, from https://medlineplus.gov/druginfo/meds/a682132.html
6. DailyMed. (n.d.). Oxycodone hydrochloride tablets, USP, for oral use, CII. U.S. National Library of Medicine. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=7ec1ff9d-221f-463e-b2d4-5a0360b9c4d2&type=display
7. Substance Abuse and Mental Health Services Administration. (2025, September 23). Misuse of prescription opioids, opioids, and fake pills. Retrieved from https://www.samhsa.gov/substance-use/learn/prescriptions-opioids
8. National Institute on Drug Abuse. (2024, November 22). Opioids. National Institutes of Health. Retrieved from https://nida.nih.gov/research-topics/opioids